Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives in antiviral chemotherapy.

J M Huraux1, D Ingrand, H Agut

  • 1Groupe Hospitalier Pitié-Salpêtrière, Laboratoire de Bactériologie-Virologie, Paris, France.

Fundamental & Clinical Pharmacology
|January 1, 1990
PubMed
Summary

Antiviral therapies target viral multiplication steps, but face challenges like side effects, resistance, and latent infections. A new approach using antisense oligonucleotides shows promise for controlling latent viral infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medecine et maladies infectieuses·2024
Same author

Medecine et maladies infectieuses·2024
Same author

[Identification of a third human polyomavirus].

Virologie (Montrouge, France)·2023
Same author

[Journée de virologie structurale SFM-SGM Nantes, 31 mai 2007].

Virologie (Montrouge, France)·2022
Same author

[Acquired resistance of herpesviruses to antivirals: a matter of concern?]

Virologie (Montrouge, France)·2022
Same author

[Virologie is 10 years old].

Virologie (Montrouge, France)·2021

Area of Science:

  • Virology
  • Pharmacology
  • Molecular Biology

Background:

  • Antiviral therapy advances stem from understanding viral multiplication cycles.
  • Current drugs target viral penetration, release, or DNA polymerase.

Purpose of the Study:

  • To review current antiviral therapies and their limitations.
  • To introduce a novel approach for controlling latent viral infections.

Main Methods:

  • Review of existing antiviral drugs (e.g., Amantadine, Rimantadine, nucleoside analogs, pyrophosphate derivatives).
  • Discussion of challenges in antiviral chemotherapy: cytotoxicity, drug resistance, and latent infection eradication.
  • Introduction of antisense oligonucleotides and hybridons as a potential new strategy.

Related Experiment Videos

Main Results:

  • Existing antiviral drugs target specific viral multiplication stages.
  • Significant obstacles include cellular toxicity, viral genetic variability leading to resistance, and failure to eradicate latent infections.
  • Antisense oligonucleotides and hybridons represent a novel strategy for latent infection control.

Conclusions:

  • Antiviral drug development requires addressing limitations of current therapies.
  • Novel approaches like antisense oligonucleotides are crucial for overcoming challenges in viral infection management, particularly latent infections.