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[Percutaneous coronary excimer laser angioplasty]
K R Karsch1, K K Haase, M Mauser
1Medizinische Klinik, Abteilung Kardiologie, Universität Tübingen.
Herz
|August 1, 1990
Summary
Pulsed excimer laser coronary angioplasty shows promise for atherosclerotic plaque ablation. Further research is needed to optimize catheter technology and improve treatment success rates for patients.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Laser Technology
Background:
- Atherosclerotic plaque ablation is achievable with pulsed excimer laser coronary angioplasty.
- Current success rates are suboptimal, necessitating advancements in catheter technology.
Purpose of the Study:
- To evaluate different excimer laser systems for coronary plaque ablation.
- To enhance the acute success rate of laser coronary angioplasty through improved catheter technology.
Main Methods:
- Investigated three excimer laser systems (308 nm wavelength) with varying pulse widths (60-220 ns) and transmission systems.
- Utilized catheter systems with fiber diameters of 100-200 microns and varying ablative tip areas (15-45%).
- Compared energy densities (25-35 mJ/mm2) and assessed catheter flexibility and steerability.
Main Results:
- Preliminary studies show variable success rates, with initial series achieving 40-45% treatment success.
- Different pulse widths and catheter designs yielded varying ablative areas and flexibility.
- Flexibility allows treatment of proximal and mid-vessel plaques, though inferior to balloon angioplasty.
Conclusions:
- Excimer laser angioplasty is a viable method for atherosclerotic plaque ablation.
- Optimizing pulse width and catheter design is crucial for improving treatment efficacy.
- Further investigation is required to determine the optimal parameters for shorter pulse widths and comparable energy densities.