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Do rhodium bis(σ-amine-borane) complexes play a role as intermediates in dehydrocoupling reactions of amine-boranes?

Valeria Butera1, Nino Russo, Emilia Sicilia

  • 1Department of Chemistry, Università della Calabria, 87036 Arcavacata di Rende.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 23, 2011
PubMed

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Nitriles can be reduced to primary amines using reducing agents like lithium aluminum hydride or catalytic hydrogenation. The reduction introduces an amino group with an extra carbon in the skeleton. Nitriles are formed from the reaction between alkyl halides and sodium cyanide through the SN2 mechanism. Primary alkyl halides are the preferred substrates to prepare nitriles.
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