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Hormone epidermal growth factor interactions in development.

D A Fisher1

  • 1UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance.

Hormone Research
|January 1, 1990
PubMed
Summary
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Epidermal growth factor (EGF) and related growth factors signal through a common receptor. Hormones like thyroid and steroids may influence growth and development by modulating EGF signaling pathways.

Area of Science:

  • Cell biology
  • Endocrinology
  • Developmental biology

Background:

  • Epidermal growth factor (EGF) is a key growth factor acting via a specific plasma membrane receptor.
  • The EGF receptor family includes transforming growth factor-alpha (TGF-alpha) and amphiregulin.
  • This receptor is present in various fetal and postnatal tissues.

Purpose of the Study:

  • To investigate the role of EGF and its receptor in fetal and neonatal development.
  • To explore the relationship between hormones and EGF signaling in growth processes.

Main Methods:

  • The abstract does not specify the methods used.
  • The study focuses on the distribution and modulation of EGF and its receptor.

Main Results:

Related Experiment Videos

  • Transforming growth factor-alpha (TGF-alpha) is the predominant family member in fetal tissues.
  • EGF production matures during the perinatal period.
  • Receptor activation in early life triggers significant growth and developmental effects in rodents.

Conclusions:

  • Tissue concentrations of EGF and its receptor are influenced by thyroid hormones, estrogen, testosterone, and growth hormone.
  • These hormonal modulations suggest that EGF signaling may mediate some growth and developmental actions of thyroid and steroid hormones.