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Updated: May 27, 2026
10:51
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Obesity and breast cancer
1Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. jligibel@partners.org
Oncology (Williston Park, N.Y.)
|November 24, 2011
Summary
Obesity increases breast cancer recurrence and death risk in women. Weight loss interventions may improve outcomes for breast cancer patients with excess body weight.
Area of Science:
- Oncology
- Endocrinology
- Epidemiology
Background:
- Obesity is a global health concern linked to increased postmenopausal breast cancer risk.
- Overweight and obesity are associated with poorer prognosis in early-stage breast cancer patients.
- Weight gain after diagnosis may also negatively impact breast cancer outcomes.
Purpose of the Study:
- To review evidence linking obesity to breast cancer recurrence.
- To discuss biological mechanisms of obesity's impact on breast cancer prognosis.
- To summarize weight-loss intervention studies in breast cancer populations.
Main Methods:
- Literature review of observational studies and clinical trials.
- Analysis of data on obesity, weight gain, and breast cancer outcomes.
- Synthesis of findings on biological pathways and intervention efficacy.
Main Results:
- Numerous studies show overweight/obese women have higher recurrence and mortality rates.
- Evidence suggests post-diagnosis weight gain is also linked to adverse outcomes.
- Biological mechanisms may involve hormonal changes, inflammation, and altered metabolism.
Conclusions:
- Obesity is a significant risk factor for breast cancer recurrence and mortality.
- Understanding biological mechanisms can inform targeted interventions.
- Weight-loss interventions show promise but require further investigation in diverse populations.
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