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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: May 27, 2026

Reconstruct Human Retinoblastoma In Vitro
06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Trilateral retinoblastoma.

Y S Limn1, E Juraida, J Alagaratnam

  • 1Department of Paediatrics, Hospital Kuala Lumpur, Malaysia.

The Medical Journal of Malaysia
|November 24, 2011
PubMed
Summary
This summary is machine-generated.

Trilateral retinoblastoma, a rare hereditary cancer linking eye tumors with pineal tumors, presents a grave prognosis. This study highlights two cases with rapid, fatal outcomes, underscoring the aggressive nature of this rare disease.

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Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Related Experiment Videos

Last Updated: May 27, 2026

Reconstruct Human Retinoblastoma In Vitro
06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Genetics

Background:

  • Retinoblastoma is the most common primary intraocular malignancy in children.
  • Trilateral retinoblastoma is defined as the co-occurrence of hereditary retinoblastoma (bilateral or unilateral) with a pineal neuroblastic tumor.
  • Hereditary retinoblastoma accounts for approximately 40% of retinoblastoma cases and is associated with germline mutations in the RB1 gene.

Observation:

  • This report details two cases of trilateral retinoblastoma identified over an 8.5-year period.
  • The total cohort comprised 141 cases of retinoblastoma.
  • Both described cases exhibited a fatal clinical course.

Findings:

  • The two patients diagnosed with trilateral retinoblastoma had extremely short survival times.
  • Survival durations were recorded as 4 months and 8 months post-diagnosis.
  • The aggressive nature of trilateral retinoblastoma was evident in the rapid progression and poor outcomes.

Implications:

  • Trilateral retinoblastoma represents a particularly aggressive subtype of retinoblastoma.
  • Early recognition and understanding of the genetic basis are crucial for managing this rare condition.
  • Further research into the molecular mechanisms and potential therapeutic targets for trilateral retinoblastoma is warranted to improve patient outcomes.