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Related Concept Videos

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Radicals: Electronic Structure and Geometry01:07

Radicals: Electronic Structure and Geometry

This lesson delves into the geometry of a radical, which is influenced by the electronic structure of the molecule. The principle is similar to that of a lone pair, where the unpaired electron influences the geometry at the radical center.
Accordingly, the structure of a trivalent radical lies between the geometries of carbocations and carbanions. An sp2-hybridized carbocation is trigonal planar, while an sp3-hybridized carbanion is trigonal pyramidal. Here, the difference in geometry is...
Chirality in Nature02:30

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...

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Related Experiment Video

Updated: May 27, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
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Published on: February 15, 2016

Chiral hierarchical molecular nanostructures on two-dimensional surface by controllable trinary self-assembly.

Jia Liu1, Ting Chen, Xin Deng

  • 1Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Journal of the American Chemical Society
|November 24, 2011
PubMed
Summary

Researchers created novel 2D chiral hierarchical nanostructures using trinary molecular self-assembly. These flower-like structures show potential for advanced molecular recognition and enantioselective catalysis applications.

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Last Updated: May 27, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

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Published on: February 15, 2016

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
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Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Surface hierarchical nanostructures are crucial for molecular recognition and enantioselective catalysis.
  • Bottom-up fabrication methods are key for designing advanced molecular nanostructures.

Purpose of the Study:

  • To construct 2D chiral hierarchical structures via trinary molecular self-assembly.
  • To investigate the formation and characteristics of these novel molecular architectures.
  • To explore the potential applications in chiral molecular recognition and catalysis.

Main Methods:

  • Trinary molecular self-assembly involving copper phthalocyanine (CuPc), 2,3,7,8,12,13-hexahexyloxy-truxenone (TrO23), and 1,3,5-tris(10-carboxydecyloxy) benzene (TCDB).
  • High-resolution scanning tunneling microscopy (STM) for detailed structural analysis.
  • Control over structure formation by tuning component molar ratios in liquid phase.

Main Results:

  • Formation of flower-like chiral hierarchical molecular architectures with multiple generations.
  • Detailed structural analysis revealed a unified configuration with triangular shape building units (TBUs).
  • Organizational chirality arises from the off-axis edge-to-edge packing of TBUs and vertex-sharing tiling, modulating chiral voids.

Conclusions:

  • Successful fabrication of multicomponent 2D chiral hierarchical nanostructures.
  • Demonstrated control over hierarchical structure formation through component ratios.
  • Findings provide a significant foundation for designing and fabricating advanced chiral molecular nanostructures for specific applications.