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Updated: May 27, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Published on: October 18, 2024

Insulin resistance and bariatric surgery.

R S Rao¹, R Yanagisawa, S Kini

¹Department of Surgery, Division of Metabolic, Endocrine and Minimally Invasive Surgery, Diabetes and Bone Disease, Mount Sinai School of Medicine, 5 E. 98th St., New York, NY 10029, USA. raghavendra.rao@mountsinai.org

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity

|November 24, 2011

Summary

Bariatric surgery significantly improves insulin resistance, with procedures like gastric bypass and biliopancreatic diversion showing rapid effects. Sleeve gastrectomy also offers early benefits, though mechanisms require further study.

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Sleeve Gastrectomy in Mice using Surgical Clips

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Published on: November 14, 2020

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Area of Science:

Metabolic Surgery
Endocrinology
Bariatric Surgery Outcomes

Background:

Insulin resistance is a key factor in metabolic syndrome and type 2 diabetes.
Bariatric surgery is increasingly recognized for its metabolic benefits beyond weight loss.

Purpose of the Study:

To systematically review changes in insulin resistance following major bariatric surgical procedures.
To analyze the impact of different bariatric surgeries on insulin resistance using meta-analysis.

Main Methods:

Systematic literature search of Pubmed and EMBASE for studies from 1980 to 2011.
Inclusion of original research articles on widely performed bariatric procedures.
Meta-analysis of HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) changes based on follow-up duration.

Main Results:

Significant decreases in HOMA-IR were observed at various time points post-surgery, with the largest reduction at >16-18 months (-67.04%).
Gastric bypass (RYGB) and biliopancreatic diversion (BPD) demonstrated significant early reductions in insulin resistance within 2 weeks.
Sleeve gastrectomy (LSG) showed a strong trend towards early improvement and faster insulin resistance reduction compared to laparoscopic adjustable gastric banding (LAGB).

Conclusions:

Bariatric surgeries, including RYGB, BPD, and LSG, lead to substantial and early improvements in insulin resistance.
The rapid metabolic improvements suggest mechanisms beyond weight loss, warranting further investigation.