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Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired

Ting-Yen Chiang1, Ling-Yuh Shyu, Thomas-Chang Yao Tsao

  • 1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Clinical Chemistry and Laboratory Medicine
|November 24, 2011
PubMed
Abstract

Insights

Elevated plasma matrix metalloproteinase-9 (MMP-9) levels are associated with community-acquired pneumonia (CAP) and may serve as a diagnostic marker. MMP-9 gene polymorphisms were not linked to CAP risk in this study.

Area of Science:

  • Biochemistry
  • Genetics
  • Pulmonology

Background:

  • Community-acquired pneumonia (CAP) poses a significant health burden.
  • Matrix metalloproteinase-9 (MMP-9) is implicated in inflammatory processes.
  • Understanding MMP-9's role in CAP is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the association between plasma MMP-9 concentration, MMP-9 gene single nucleotide polymorphisms (SNPs), and CAP.
  • To evaluate plasma MMP-9 as a potential diagnostic biomarker for CAP.

Main Methods:

  • Plasma MMP-9 levels were measured using enzyme-linked immunosorbent assay (ELISA).
  • MMP-9 gene polymorphisms (rs3918242, rs17576, rs2274756) were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Main Results:

  • Plasma MMP-9 levels were significantly higher in CAP patients than in controls and decreased post-treatment.
  • Plasma MMP-9 concentration correlated with white blood cell and neutrophil counts.
  • No significant association was found between MMP-9 SNPs and CAP. A plasma MMP-9 cut-off of 105.02 ng/mL indicated a 9.86-fold increased risk for CAP.

Conclusions:

  • Elevated plasma MMP-9 is a potential diagnostic biomarker for CAP.
  • Plasma MMP-9 levels may guide targeted therapy strategies for CAP.
  • MMP-9 gene polymorphisms are not directly associated with CAP risk in the studied population.

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