Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Does paracetamol improve recovery after stroke?].

Inter R de Ridder¹, H Bart van der Worp, H Maarten A van Gemert

¹Erasmus Medisch Centrum, afd. Neurologie, Rotterdam, the Netherlands. i.deridder@erasmusmc.nl

Nederlands Tijdschrift Voor Geneeskunde

|November 24, 2011

Summary

High-dose paracetamol may improve stroke recovery. The PAIS 2 study investigates if acetaminophen reduces fever and enhances functional outcomes in stroke patients with elevated body temperature.

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tirofiban and thrombectomy for acute ischaemic stroke.

Lancet (London, England)·2026

Same author

Disparities in Prehospital Stroke Care: Neighbourhood Socioeconomic Status and Delays in Hospital Presentation.

Cerebrovascular diseases (Basel, Switzerland)·2026

Same author

Mapping the mRS Into the EQ-5D-5L in Patients With Ischemic Stroke.

Stroke·2026

Same author

Endovascular treatment in patients with renal dysfunction: results of the MR CLEAN Registry.

European stroke journal·2026

Same author

Imaging Modalities to Visualize Deep Cerebral Perforating Arteries: A Systematic Review and Meta-analysis.

AJNR. American journal of neuroradiology·2026

Same author

Validity of intracerebral haemorrhage volume assessment: comparison of fully automated segmentation analysis with manual ABC/2 and semi-automated measurement.

European stroke journal·2026

Area of Science:

Neurology
Pharmacology

Context:

Elevated body temperature post-stroke correlates with poor functional outcomes.
Paracetamol (acetaminophen) effectively reduces fever with minimal side effects.

Purpose:

To confirm the beneficial effect of high-dose paracetamol on functional outcomes in acute stroke patients with fever.
To validate findings from the initial Paracetamol (Acetaminophen) in Stroke (PAIS) study.

Summary:

The randomized PAIS 2 study assesses high-dose paracetamol's impact on functional outcomes in acute stroke patients (body temperature ≥37.0°C).
Previous subgroup analysis of the PAIS study suggested a positive effect of paracetamol in this patient group.

Impact:

This research could establish a simple, cost-effective treatment to improve stroke patient recovery.

Related Experiment Videos

Results may influence clinical guidelines for fever management in acute stroke.