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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Parenteral fluoroquinolones in children with life-threatening infections

R Dagan1, F Schlaeffer, M Einhorn

  • 1Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel.

Infection
|July 1, 1990
PubMed

Insights

New fluoroquinolones, despite cartilage concerns in young animals, can be life-saving for children. This study shows successful treatment of severe pediatric infections when other antibiotics failed, highlighting their critical role in specific cases.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Fluoroquinolones possess broad-spectrum activity but are typically avoided in children due to observed cartilage damage in animal studies.
  • Despite safety concerns, fluoroquinolones may be essential in treating life-threatening pediatric infections unresponsive to standard therapies.

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