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[Invasive aspergillosis with extrapulmonary involvement: pathogenesis, clinical characteristics and prognosis]

Luis Eduardo López-Cortés1, Carolina Garcia-Vidal, Josefina Ayats

  • 1Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, España.

Revista Iberoamericana De Micologia
|November 24, 2011
PubMed
Abstract

Insights

Invasive aspergillosis with extrapulmonary involvement is rare. Invasive sinusitis has a lower mortality, while other forms associated with immunosuppression or surgery have a high mortality rate.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Context:

  • Invasive aspergillosis incidence is rising globally.
  • Extrapulmonary involvement data is limited.
  • This study focuses on a rare presentation of invasive aspergillosis.

Purpose:

  • To describe the pathogenesis, characteristics, and outcomes of invasive aspergillosis with extrapulmonary disease.
  • To identify common clinical manifestations and associated risk factors.
  • To evaluate treatment strategies and patient prognoses.

Summary:

  • A retrospective study identified 12 cases of invasive aspergillosis with extrapulmonary involvement.
  • Common manifestations include invasive sinusitis, prosthetic valve endocarditis, fungaemia, meningitis, brain abscesses, and spondylitis.
  • Aspergillus fumigatus, flavus, and niger were the identified species.

Impact:

  • Invasive sinusitis cases had a survival rate of 100%.
  • Other extrapulmonary forms had an 88% mortality rate, often linked to immunosuppression or surgery.
  • Findings highlight the importance of early diagnosis and targeted treatment for better outcomes.

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