Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hemostasis in hemodilution--1) Hematocrit.

G Dietrich1, V Kretschmer, D Orth

  • 1Department of Transfusion Medicine and Coagulation Physiology, University Clinics, Marburg, FRG.

Infusionstherapie (Basel, Switzerland)
|August 1, 1990
PubMed
Summary

Acute preoperative hemodilution significantly impairs primary hemostasis. Lower hematocrit levels were inversely correlated with longer bleeding times, suggesting altered hemorheology and red cell-platelet interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incorporating the concept of overtransfusion into hemovigilance monitoring: An expert-based definition and criteria from the International HIT-OVER Forum.

Transfusion·2024
Same author

The Effect of Pedagogical Approach on Physical Activity of Girls During Physical Education.

Research quarterly for exercise and sport·2024
Same author

[Delays and pathways for patients with endometriosis in France: A multicenter study].

Gynecologie, obstetrique, fertilite & senologie·2022
Same author

[Safety of cell salvage in tumor surgery : Systematic review with meta-analysis].

Der Anaesthesist·2020
Same author

Effect of robotic-assisted gait rehabilitation on dynamic equilibrium control in the gait of children with cerebral palsy.

Gait & posture·2017
Same author

Robotic-assisted gait training improves walking abilities in diplegic children with cerebral palsy.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2017

Area of Science:

  • Hematology
  • Hemostasis
  • Surgical Research

Background:

  • Controversies exist regarding acute preoperative hemodilution's effect on coagulation.
  • Understanding hemodilution's impact on primary hemostasis is crucial for surgical patient safety.

Purpose of the Study:

  • To investigate the influence of acute preoperative hemodilution on platelet function and primary hemostasis.
  • To determine the relationship between hematocrit levels and bleeding parameters.

Main Methods:

  • Utilized the In-vitro bleeding test (IVBT) on composed blood samples.
  • Varied hematocrit levels while maintaining constant platelet concentration.
  • Analyzed bleeding time, volume, and flow.

Main Results:

Related Experiment Videos

  • An inverse correlation was observed between hematocrit and bleeding time (p < .05).
  • Significant inverse correlations were found between hematocrit and bleeding volume (p < .001) and flow (p < .001).
  • Lower hematocrit levels were associated with prolonged bleeding.

Conclusions:

  • Acute preoperative hemodilution significantly impairs primary hemostasis.
  • Reduced hematocrit likely alters hemorheology and red cell-platelet interactions, leading to impaired platelet function.
  • These findings highlight potential risks associated with hemodilution in surgical settings.