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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Related Experiment Video

Updated: May 27, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Bone remodelling around a cementless glenoid component.

Daniel R Suárez1, Harrie Weinans, Fred van Keulen

  • 1F. de Ingeniería, Pontificia Universidad Javeriana, Bogotá, Colombia. d-suarez@javeriana.edu.co

Biomechanics and Modeling in Mechanobiology
|November 24, 2011
PubMed
Summary
This summary is machine-generated.

Bone density changes around cementless glenoid components, with some resorption occurring regardless of implant fixation. Interface condition slightly influences bone resorption, but micromotions remain minimal with ideal fixation.

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Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
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Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

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Last Updated: May 27, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
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Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
09:08

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

Area of Science:

  • Orthopedic Surgery
  • Biomechanical Engineering
  • Materials Science

Background:

  • Post-operative mechanical loading changes can induce bone adaptation, potentially compromising cementless prosthesis stability.
  • Bone's self-fixation in cementless components makes understanding bone remodeling crucial for long-term implant success.

Purpose of the Study:

  • To investigate bone remodeling around a cementless glenoid component.
  • To compare bone adaptation under fully bonded versus completely loose implant conditions.

Main Methods:

  • Creation of 3D finite element models of a scapula with and without a cementless glenoid component.
  • Utilizing cadaver-derived scapula geometry, material properties, and physiological loading conditions.
  • Implementing a node-based bone remodeling scheme driven by strain energy density to simulate bone adaptation.

Main Results:

  • Average bone density in the glenoid increased post-implantation.
  • Significant local bone resorption occurred near the bone-implant interface, irrespective of fixation.
  • Bone resorption was marginally greater with a loose interface compared to a bonded one.

Conclusions:

  • Bone remodeling around cementless glenoid components involves both density increases and localized resorption.
  • The interface condition (bonded vs. loose) influences the extent of bone resorption.
  • Ideal screw fixation effectively minimizes interface micromotions during bone adaptation.