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Transient and mild reduction of consciousness during febrile illness in children
T Kato1, A Okumura, F Hayakawa
1Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan. kato-jes@umin.ac.jp
Insights
Transient mild reduction of consciousness in children during febrile illness is a distinct clinical group. This study found no significant differences in clinical, MRI, or EEG findings between children with or without delirious behavior.
Area of Science:
- Pediatrics
- Neurology
Background:
- Febrile illness in children can cause transient, mild reductions in consciousness.
- Understanding the characteristics of this condition is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the clinical and neuroimaging features of children experiencing transient, mild consciousness reduction during febrile illness.
- To compare patients with and without delirious behavior.
Main Methods:
- Retrospective evaluation of 58 children admitted with mild consciousness reduction during febrile illness.
- Comparison of clinical, brain MRI, and EEG findings between groups with and without delirious behavior.
Main Results:
- 91% of patients exhibited delirious behavior; 9% did not.
- No statistically significant differences in clinical, MRI, or EEG findings were observed between the groups.
- Reversible white matter lesions were noted on MRI in some patients.
- Transient EEG abnormalities were observed in both groups.
Conclusions:
- Transient, mild consciousness reduction during febrile illness represents a unique clinical entity.
- This condition includes children with and without delirious behavior.
- Further research may elucidate specific underlying mechanisms.
Abstract:
We have studied the clinical and neuroimaging characteristics of transient and mild reduction of consciousness during febrile illness in children. We retrospectively evaluated 58 children admitted with mild reduction of consciousness within 12 h during febrile illness. 53 patients (91%) had delirious behavior, and 5 (9%) had no delirious behavior. We also compared the clinical characteristics, brain magnetic resonance imaging (MRI) findings, and electroencephalography (EEG) findings between patients with and without delirious behavior, and no statistically significant differences were observed in any of them between the 2 patient groups (P≥0.05). MRI was performed 0-4 days after onset in 23 patients. Reversible splenial or callosal and white matter lesions were observed in 2 of 3 patients without delirious behavior vs. 4 of 20 patients with delirious behavior on diffusion-weighted images. EEG was performed 0-3 days after onset in 29 patients. Transient abnormal findings were observed in 3 of 4 patients without delirious behavior vs. 11 of 25 patients with delirious behavior. In conclusion, we consider that transient and mild reduction of consciousness during febrile illness is a unique clinical group that is constituted by children both with and without delirious behavior.
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