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Updated: May 27, 2026

Studying Food Reward and Motivation in Humans
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Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Measuring extrastriatal dopamine release during a reward learning task.

Elske Vrieze1, Jenny Ceccarini, Diego A Pizzagalli

  • 1Department of Psychiatry, University Hospital Leuven, Belgium. elske.vrieze@uc-kortenberg.be

Human Brain Mapping
|November 24, 2011
PubMed
Summary
This summary is machine-generated.

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Dopamine release in key brain regions like the mOFC, vmPFC, and dACC is vital for human reward learning. This study reveals how dopamine function in these areas relates to anhedonia and behavioral adjustments.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Reward learning is essential for survival and is primarily studied in animals.
  • The role of extrastriatal dopamine (DA) in human reward learning remains underexplored.
  • Mesocorticolimbic pathways are implicated, but extrastriatal DA functioning requires further investigation.

Purpose of the Study:

  • To investigate presynaptic dopamine release in extrastriatal regions of the human reward circuit.
  • To measure endogenous dopamine release using [(18)F]Fallypride positron emission tomography during a reward task.
  • To correlate dopamine release with reward task performance and anhedonia.

Main Methods:

  • Ten healthy volunteers underwent [(18)F]Fallypride PET scans while performing a reward task.

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  • Assessed participants' ability to modify behavior based on reward feedback.
  • Correlated radioligand displacement (indicating DA release) with behavioral outcomes and self-reported anhedonia.

    • Main Results:

    • Significant endogenous dopamine release was observed in the medial orbitofrontal cortex (mOFC), ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC).
    • Increased anhedonia correlated with greater dopamine release in the vmPFC and dACC.
    • Reduced reward learning and impaired behavioral modulation correlated with higher dopamine release in the vmPFC and dACC.

    Conclusions:

    • Dopamine release in the mOFC, vmPFC, and dACC is crucial for reinforcement learning in humans.
    • These findings highlight the role of extrastriatal dopamine in reward-guided behavior.
    • The study provides novel insights into the neurobiological underpinnings of reward processing and its relation to anhedonia.