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Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Antibiotic Selection00:57

Antibiotic Selection

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Related Experiment Video

Updated: May 27, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

DAMPD: a manually curated antimicrobial peptide database.

Vijayaraghava Seshadri Sundararajan1, Musa Nur Gabere, Ashley Pretorius

  • 1South African National Bioinformatics Institute, The University of the Western Cape, 7535 Bellville, South Africa.

Nucleic Acids Research
|November 24, 2011
PubMed
Summary
This summary is machine-generated.

The Dragon Antimicrobial Peptide Database (DAMPD) offers a valuable resource for researchers seeking antimicrobial peptides (AMPs). This manually curated database aids in the development of novel anti-infectious agents to combat antibiotic-resistant pathogens.

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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

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Last Updated: May 27, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Area of Science:

  • Biochemistry
  • Microbiology
  • Bioinformatics

Background:

  • Increasing antibiotic resistance necessitates new anti-infectious agents.
  • Naturally occurring antimicrobial peptides (AMPs) show promise as templates for novel therapeutics.
  • A centralized, curated resource for AMP information is crucial for research and development.

Purpose of the Study:

  • To develop and present the Dragon Antimicrobial Peptide Database (DAMPD) as a comprehensive resource for AMPs.
  • To replace and update the existing ANTIMIC database with enhanced features and data.
  • To facilitate the discovery and analysis of antimicrobial peptides for therapeutic development.

Main Methods:

  • Manual curation of 1232 antimicrobial peptides.
  • Development of an integrated web interface for DAMPD (http://apps.sanbi.ac.za/dampd).
  • Integration of bioinformatics tools including Blast, ClustalW, HMMER, Hydrocalculator, SignalP, and an AMP predictor.

Main Results:

  • The DAMPD contains 1232 manually curated antimicrobial peptides.
  • An integrated interface allows for advanced searching by taxonomy, species, family, citation, and keywords.
  • Multiple bioinformatics tools are integrated to support biological analysis of AMPs.

Conclusions:

  • DAMPD serves as a significant update and replacement for the ANTIMIC database.
  • The database and its integrated tools streamline the search and analysis of antimicrobial peptides.
  • DAMPD supports the ongoing research into novel anti-infectious agents to combat resistant pathogens.