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06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Migraine and hypercoagulable states in ischemic stroke
P Martínez-Sánchez1, M Martínez-Martínez, B Fuentes
1IdiPAZ Health Research Institute, Spain.
Cephalalgia : an International Journal of Headache
|November 24, 2011
Summary
Migraine, particularly migraine with aura, may increase the risk of hypercoagulable states in young ischemic stroke patients. This study found a higher prevalence of these conditions in migraineurs with brain ischemia.
Area of Science:
- Neurology
- Hematology
- Vascular Medicine
Background:
- The link between migraine and hypercoagulable states (HS) in ischemic stroke patients remains unclear.
- Investigating this association is crucial for understanding stroke etiology in younger individuals.
Purpose of the Study:
- To determine if migraine is associated with an increased prevalence of hypercoagulable states in patients experiencing ischemic stroke.
- To explore the specific roles of migraine with aura (MA) and migraine without aura (MO) in this association.
Main Methods:
- Prospective study of 154 ischemic stroke patients under 55 years old.
- Systematic questionnaires assessed migraine history (MA or MO).
- Extensive hematological tests identified hypercoagulable states; patent foramen ovale (PFO) was assessed via echocardiography.
Main Results:
- Hypercoagulable states were significantly more frequent in patients with migraine (38.6%) compared to those without (16.4%).
- Migraine without aura (MO) showed a 2.88-fold increased risk of HS.
- Migraine with aura (MA) was independently associated with HS in patients under 50 with brain infarction (OR 6.81).
Conclusions:
- Migraine may be linked to a higher incidence of hypercoagulable states in young ischemic stroke patients.
- Migraine with aura appears to be a significant independent risk factor for HS in this demographic.
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