Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraocular radiation blocking.

P T Finger1, T K Ho, D M Fastenberg

  • 1Department of Ophthalmology, North Shore University Hospital, Cornell University Medical College, Manhasset, NY 11030.

Investigative Ophthalmology & Visual Science
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High serum lactate as an adjunct in the early prediction of anastomotic leak following oesophagectomy.

International journal of surgery (London, England)·2017
Same author

Investigation of outbreaks of Pneumocystis jirovecii pneumonia in two Scottish renal units.

The Journal of hospital infection·2017
Same author

Inactivation of Proteolytic Enzymes from Porphyromonas gingivalis Using Light-activated Agents.

Lasers in medical science·2014
Same author

Accurate whole-spectrum measurements of intracellular pH and [Na(+)].

Journal of fluorescence·2013
Same author

Small bowel evisceration through the anus--report of a case and review of literature.

BMJ case reports·2012
Same author

Subconjunctival ranibizumab for squamous cell carcinoma of the conjunctiva with corneal extension.

The British journal of ophthalmology·2009
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

Iodine contrast agents can shield eyes from radiation during Iodine-125 plaque therapy. Iohexol showed promise with minimal toxicity, unlike iophendylate which caused ocular damage.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Imaging

Background:

  • Iodine-125 (125I) plaque radiotherapy is used for ocular tumors.
  • Protecting healthy ocular tissues from radiation is crucial.
  • Radiopaque contrast agents offer potential for shielding.

Purpose of the Study:

  • To evaluate iodine-based contrast agents for shielding ocular structures during 125I radiotherapy.
  • To assess the radiation attenuation properties of intraocular contrast agents.
  • To determine the ocular toxicity and transit times of different contrast agents.

Main Methods:

  • Intraocular injection of iodine-based contrast agents (iohexol, iophendylate) in normal and tumor-bearing rabbit eyes.
  • In vivo dosimetry using thermoluminescent dosimeters (TLDs) to measure radiation attenuation.

Related Experiment Videos

  • Computed tomography (CT) imaging to assess contrast agent transit time.
  • Ocular toxicity assessment at 7 and 31 days post-injection.

    • Main Results:

    • Intraocular contrast agents significantly attenuated 125I radiation compared to saline controls.
    • Aqueous-based iohexol demonstrated rapid transit, while oil-like iophendylate had slow transit.
    • Iophendylate induced intraocular inflammation and retinal degeneration.
    • Iohexol-treated eyes showed no significant toxicity compared to controls.

    Conclusions:

    • Intraocular radiopaque materials can effectively shield normal ocular structures during 125I plaque irradiation.
    • Iohexol is a potential candidate for intraocular shielding due to its efficacy and safety profile.
    • Further research is needed to develop methods preventing contrast agent extrusion from the eye for clinical application.