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Ceftriaxone associated urolithiasis in a child with hypercalciuria

V J Lozanovski, Z Gucev, V J Avramoski

    Hippokratia
    |November 24, 2011
    PubMed

    Insights

    A child developed kidney stones made of calcium-ceftriaxonate during pneumonia treatment with Ceftriaxone. Moderate hypercalciuria may contribute to this Ceftriaxone-associated nephrolithiasis.

    Area of Science:

    • Pediatric Nephrology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Ceftriaxone is a common antibiotic used to treat bacterial infections in children.
    • Nephrolithiasis (kidney stones) is a potential, though uncommon, adverse effect of certain antibiotics.

    Observation:

    • A 5-year-old boy with pneumonia experienced right lumbar pain on day 7 of Ceftriaxone treatment.
    • Ultrasound revealed right hydronephrosis, and spontaneous passage of three calculi occurred.
    • Infrared spectroscopy identified the calculi as calcium-ceftriaxonate.

    Findings:

    • The patient presented with Ceftriaxone-induced nephrolithiasis.
    • Metabolic investigation revealed moderate hypercalciuria.
    • Hypercalciuria is suggested as a contributing factor to Ceftriaxone-associated kidney stone formation.

    Implications:

    • This case highlights the risk of Ceftriaxone-associated nephrolithiasis, particularly in patients with underlying metabolic abnormalities like hypercalciuria.
    • Early recognition and management of lumbar pain during Ceftriaxone therapy are crucial.
    • Further research into the mechanisms and prevention of antibiotic-associated kidney stones is warranted.

    Keywords:
    biliary pseudolithiasisceftriaxonechildhypercalciuriainfrared spectroscopyurolithiasis

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