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Updated: May 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes
Hassan Mansouri-Torshizi1, Maryam Saeidifar, Fatemeh Khosravi
1Department of Chemistry, University of Sistan and Baluchestan, Zahedan 98167-45345, Iran.
Abstract:
The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO(3) (Oct-dtc = Octyldithiocarbamate and bpy = 2,2' -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO(3), have been synthesized and characterized by elemental analyses, molar conductivity measurements, IR, (1)H NMR, and electronic spectra studies. Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out. They show Ic(50) values lower than that of cisplatin. The complexes have been investigated for their interaction with calf thymus DNA (CT-DNA) by utilizing the electronic absorption spectroscopy, fluorescence spectra, and ethidium bromide displacement and gel filtration techniques. Both of these water-soluble complexes bound cooperatively and intercalatively to the CT-DNA at very low concentrations. Several binding and thermodynamic parameters are also described.
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