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Published on: February 10, 2011

Clinical Features and Rate of Infective Endocarditis in Non-Faecalis and Non-faecium Enterococcal Bacteremia

Hee-Chang Jang1, Wan Beom Park, Hong Bin Kim

  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Chonnam Medical Journal
|November 24, 2011
PubMed

Insights

Non-faecalis and non-faecium enterococci rarely cause infective endocarditis compared to Enterococcus faecalis bacteremia. This study found a significantly lower rate of infective endocarditis in patients with non-faecalis and non-faecium enterococcal bacteremia.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Enterococci are a significant cause of hospital-acquired infections.
  • While Enterococcus faecalis is a common cause of enterococcal bacteremia and endocarditis, other enterococcal species are less understood.
  • The clinical implications and endocarditis risk of non-faecalis and non-faecium enterococcal bacteremia remain unclear.

Purpose of the Study:

  • To compare the clinical features of non-faecalis and non-faecium enterococcal bacteremia with Enterococcus faecalis bacteremia.
  • To determine the rate of infective endocarditis in non-faecalis and non-faecium enterococcal bacteremia.

Main Methods:

  • Retrospective comparison of 70 cases of non-faecalis and non-faecium enterococcal bacteremia with 65 cases of Enterococcus faecalis bacteremia.
  • Analysis of clinical features, including source of infection and presence of polymicrobial bacteremia.
  • Assessment of the incidence of infective endocarditis in both groups.

Main Results:

  • Non-faecalis and non-faecium enterococcal bacteremia showed a higher association with biliary tract infections (57% vs. 28%) and polymicrobial bacteremia (47% vs. 31%) compared to E. faecalis.
  • Infective endocarditis was significantly less frequent in non-faecalis and non-faecium enterococcal bacteremia (1%) than in E. faecalis bacteremia (14%).
  • The difference in infective endocarditis rates was statistically significant (p<0.01).

Conclusions:

  • Non-faecalis and non-faecium enterococci are associated with different clinical presentations than E. faecalis bacteremia.
  • The risk of developing infective endocarditis is substantially lower for non-faecalis and non-faecium enterococcal bacteremia compared to E. faecalis bacteremia.
Keywords:
BacteremiaEndocarditisEnterococcivanC

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