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Updated: May 27, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Surgical treatment for ischemic cardiomyopathy]
1Department of Cardiovascular Surgery, Osaka University, Suita, Japan.
Abstract:
The efficacy of regenerative cell therapy as strategy of cardiac functional recovery in patients with end-stage heart failure has been recently reported, and clinical applications of autologous skeletal myoblast cell transplantation has been already started in Europe and Unitd States. We developed cell sheet technology with a temperature-responsive culture dish, which enabled cell-to-cell junction to retain, and started a clinical study of cardiac regenerative therapy using autologous skeletal myoblast cell sheet implantation.
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