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Recurrent intracranial haemorrhages in a patient with factor seven deficiency: a case report

F Fadzil1

  • 1Jabatan Neurosains, Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia, Kampus Kesihatan, 16150 Kubang Kerian, Kelantan. nurelisha@yahoo.com

The Medical Journal of Malaysia
|November 25, 2011
PubMed

Inherited factor VII (FVII) deficiency is a rare autosomal recessive hemorrhagic disorder. Clinical bleeding can vary widely and does not always correlate with the level of FVII coagulant activity measured in plasma. Most severe cases of factor VII (FVII) deficiency are diagnosed during childhood, often during the first 6 months of life. In infancy, the most common sites of bleeding occur in the gastrointestinal tract or CNS, accounting for 60-70% of bleeds in this age group. Recombinant factor VIIa (rFVIIa) is one such agent, which has been shown to prevent hematoma expansion and improve outcome in acute intracranial haemorrhages. The purpose of this case report is to share our experience regarding the usefulness of rFVIIa in the management of acute intracranial haemorrhage.

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