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Updated: May 27, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Approaches to the pharmacological treatment of obesity
Victoria Salem1, Stephen R Bloom
1Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK. v.salem@imperial.ac.uk.
Abstract:
Obesity is a global health crisis resulting in major morbidity and premature death. The need for safe and efficacious drug therapies is great, and presently unmet. The two drugs currently licensed in the USA for the long-term treatment of obesity, orlistat and sibutramine, provide only modest weight-loss benefits and are associated with high attrition rates owing to side effects. This review summarizes current concepts in the neuroendocrine control of energy homeostasis and major pharmacological treatments for obesity in the pipeline.
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