Diagnosis and individual treatment of cardiovascular diseases: targeting vascular oxidative stress

Area of Science:

• Biomedical research
• Cardiovascular medicine
• Oxidative stress

Background:

• Cardiovascular diseases (CVDs) are a leading global cause of mortality and morbidity.
• Current CVD treatments are often symptom-oriented and lack personalization.
• A deeper understanding of CVDs' underlying mechanisms is crucial for effective prevention and treatment.

Purpose of the Study:

• To explore the role of oxidative stress in cardiovascular disease pathogenesis.
• To propose novel therapeutic strategies beyond traditional antioxidant supplements.
• To highlight the potential of individualized medicine in managing CVDs.

Main Methods:

• Reviewing the limitations of current antioxidant supplement approaches for CVDs.
• Investigating oxidative stress as a key mechanism in endothelial dysfunction.
• Identifying enzymatic sources of reactive oxygen species in the vascular wall.
• Exploring emerging biomarkers for oxidative stress in CVDs.

Main Results:

• Traditional antioxidant supplements have proven ineffective for CVDs.
• Oxidative stress, driven by reactive oxygen species, contributes to endothelial dysfunction.
• Targeting enzymatic sources of oxidative stress presents a promising alternative.
• Emerging biomarkers can aid in monitoring oxidative stress levels.

Conclusions:

• Individualized medicine, incorporating diagnostics, molecular imaging, and mechanism-based drugs, is essential for advancing CVD care.
• Targeting the enzymatic origins of oxidative stress offers a more effective strategy than general antioxidant supplementation.
• This approach promises more individualized, effective, and cost-efficient CVD management.