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Reduction of image artifacts induced by change in the optode coupling in time-resolved diffuse optical tomography
Ryo Fukuzawa1, Shinpei Okawa, Shoko Matsuhashi
1University of Electro-Communications, Department of Mechanical Engineering and Intelligent Systems, Chofu, Tokyo, Japan.
Journal of Biomedical Optics
|November 25, 2011
Summary
This study introduces optode calibration using coupling coefficients into time-domain diffuse optical tomography (DOT) to reduce image artifacts. The method effectively minimizes artifacts caused by changing optode coupling in reconstructed absorption coefficient images.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Optical Physics
Background:
- Diffuse optical tomography (DOT) reconstructs optical property images using inversion algorithms.
- Artifacts in DOT images can arise from changes in optode coupling during measurements.
- Previous methods incorporated coupling coefficients effectively for continuous wave- and frequency-domain DOT.
Purpose of the Study:
- To investigate the impact of optode calibration on reconstructed images in time-domain DOT.
- To assess the effectiveness of incorporating coupling coefficients into time-domain DOT algorithms.
- To reduce artifacts caused by optode coupling variations in time-domain DOT.
Main Methods:
- Incorporation of coupling coefficients into a time-domain DOT algorithm.
- Utilized a modified generalized pulse spectrum technique for reconstruction.
- Evaluated the method through numerical simulations, phantom experiments, and in vivo studies.
Main Results:
- Reconstructed images of the absorption coefficient showed reduced artifacts due to optode coupling changes.
- The introduction of coupling coefficients proved effective for time-domain DOT.
- The algorithm's validity was confirmed across simulations, phantoms, and in vivo data.
Conclusions:
- Optode calibration via coupling coefficients is a viable strategy to mitigate artifacts in time-domain DOT.
- This approach enhances the accuracy and reliability of reconstructed optical property images.
- The validated algorithm offers improved performance for time-domain DOT applications.
