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Updated: May 27, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Periodontal pharmacotherapy - an updated review
A Leszczyńska1, P Buczko, W Buczko
1Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland. pharmdyn@umwb.edu.pl
Periodontal disease, driven by bacterial biofilms, requires mechanical plaque removal. If ineffective, antimicrobial agents like antibiotics and antiseptics are considered for treatment.
Area of Science:
- Dentistry
- Microbiology
- Pharmacology
Background:
- Periodontal disease stems from bacterial biofilms on teeth, triggering gum inflammation and immune responses.
- Initial treatment involves mechanical plaque and calculus removal.
- Non-surgical therapy failure necessitates antimicrobial agent consideration.
Purpose of the Study:
- To review current pharmacological strategies for periodontal disease.
- To emphasize systemic and local antimicrobial therapy options.
Main Methods:
- Review of recent periodontal studies on pharmacological agents.
- Analysis of treatments targeting bacteria or host immune response.
Main Results:
- No single antimicrobial agent is established as a 'gold standard'.
- Pharmacotherapy includes systemic or local antibiotics and antiseptics.
- Adjunct treatments targeting bacteria or host response are explored.
Conclusions:
- Pharmacological strategies are crucial when initial periodontal therapy fails.
- Systemic and local antimicrobial therapies are key components of periodontal treatment.
- Ongoing research seeks optimal antimicrobial approaches for periodontal disease.
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