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Related Concept Videos

Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
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Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Related Experiment Video

Updated: May 27, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Lupus and pregnancy.

Alan N Baer1, Frank R Witter, Michelle Petri

  • 1Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21239, USA. alanbaer@jhmi.edu

Obstetrical & Gynecological Survey
|November 25, 2011
PubMed
Summary

Pregnancy in women with systemic lupus erythematosus (SLE) has improved outcomes. Optimal conception timing and medication management are crucial for reducing pregnancy complications in SLE patients.

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Related Experiment Videos

Last Updated: May 27, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Area of Science:

  • Obstetrics and Gynecology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) disproportionately affects women of reproductive age.
  • Pregnancy in SLE patients historically led to poor obstetric outcomes, but recent improvements are noted.

Purpose of the Study:

  • To review the current understanding of pregnancy outcomes in women with SLE.
  • To highlight management strategies for optimizing maternal and fetal health during pregnancy in SLE patients.

Main Methods:

  • Literature review focusing on SLE pregnancy outcomes, complications, and management strategies.
  • Analysis of factors influencing pregnancy success in SLE, including disease activity, medication, and specific antibodies.

Main Results:

  • Pregnancy loss rates in SLE are now comparable to the general population.
  • Key complications include disease flares, preeclampsia, miscarriage, stillbirth, growth retardation, and preterm birth.
  • Active lupus nephritis presents the highest risk; early intervention and monitoring are vital.

Conclusions:

  • Delayed conception until SLE inactivity (≥6 months) and pre-conception medication adjustment improve outcomes.
  • Continuous hydroxychloroquine use and prophylactic aspirin/heparin for antiphospholipid antibodies are recommended.
  • Management involves careful monitoring, with specific treatments tailored to disease activity and complications, avoiding high-risk medications when possible.