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Risk factors for recurrent stroke after coronary artery bypass grafting
1Department of Anesthesiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academic Medical Science and Peking Union Medical College, Beijing, China.
Insights
Stroke risk after coronary artery bypass grafting (CABG) is significant in patients with prior stroke history. Key risk factors include unstable angina, low ejection fraction, atrial fibrillation, and hypotension.
Area of Science:
- Cardiology
- Neurology
- Surgical Outcomes
Background:
- Preventing stroke post-coronary artery bypass grafting (CABG) is crucial.
- Identifying risk factors for stroke in CABG patients with a history of stroke is essential for targeted prevention strategies.
Purpose of the Study:
- To identify independent risk factors for recurrent stroke in patients undergoing CABG who have a prior history of stroke.
Main Methods:
- Retrospective analysis of 430 patients with stroke history undergoing CABG.
- Data collected included pre-operative and post-operative variables.
- Univariate and multivariate logistic regression analyses were employed.
Main Results:
- Post-operative stroke occurred in 7.4% of patients.
- Independent risk factors identified were unstable angina (OR=2.95), left ventricular ejection fraction (LVEF) ≤50% (OR=2.77), atrial fibrillation (AF) (OR=4.69), and hypotension (OR=2.55).
Conclusions:
- Unstable angina, reduced LVEF (≤50%), post-operative AF, and post-operative hypotension are significant independent risk factors for recurrent stroke in CABG patients with a prior stroke history.
Objectives:
Preventing stroke after coronary artery bypass grafting (CABG) remains a therapeutic goal, due in part to the lack of identifiable risk factors. The aim of this study, accordingly, was to identify risk factors in CABG patients with a previous history of stroke.
Methods:
Patients with a history of stroke who underwent CABG at Beijing An Zhen hospital from January 2007 to July 2010 were selected (n = 430), and divided into two groups according to the occurrence of postoperative stroke. Pre-operative and post-operative data were retrospectively collected and analyzed by univariate and multivariate logistic regression analyses.
Results:
Thirty-two patients (7.4%) suffered post-operative stroke. Univariate analysis identified several statistically significant risk factors in the post-operative stroke group, including pre-surgical left ventricular ejection fractions (LVEF) ≤50%, on-pump surgery, post-operative atrial fibrillation (AF), and hypotension. Multivariable analysis identified 4 independent risk factors for recurrent stroke: unstable angina (odds ratio (OR) = 2.95, 95% CI: 1.05-8.28), LVEF ≤50% (OR = 2.77, 95% CI: 1.23-6.27), AF (OR = 4.69, 95% CI: 1.89-11.63), and hypotension (OR = 2.55, 95% CI: 1.07-6.04).
Conclusion:
Unstable angina, LVEF ≤50%, post-operative AF, and post-operative hypotension are independent risk factors of recurrent stroke in CABG patients with a previous history of stroke.
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