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Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Related Experiment Video

Updated: May 27, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Fibrinogen function after severe burn injury.

Eva Schaden1, David Hoerburger, Stefan Hacker

  • 1Dept. of Anesthesiology, General Intensive Care and Pain Control, Medical University Of Vienna, Austria. eva.schaden@meduniwien.ac.at

Burns : Journal of the International Society for Burn Injuries
|November 25, 2011
PubMed
Summary
This summary is machine-generated.

Fibrinogen function changes early after severe burn trauma, with levels increasing significantly 48 hours post-injury. Rotational thrombelastometry (ROTEM) effectively visualizes these fibrinogen changes using the FIBTEM test.

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Area of Science:

  • Coagulation and Thrombosis
  • Burn Trauma Pathophysiology
  • Critical Care Medicine

Background:

  • Growing evidence suggests hypercoagulability in the first week post-burn trauma.
  • Increased fibrinogen levels are a potential contributor to this hypercoagulable state.
  • Rotational thrombelastometry (ROTEM) offers functional fibrinogen assessment via FIBTEM(®).

Purpose of the Study:

  • To test the hypothesis that fibrinogen function changes over time in severe burn injury patients.
  • To simultaneously measure functional fibrinogen (FIBTEM(®)) and fibrinogen concentration early after burn trauma.

Main Methods:

  • Prospective observational study of consecutive severe burn trauma patients.
  • Blood samples collected immediately, 12, 24, and 48 hours post-admission.
  • Measured fibrinogen level (Clauss) and performed four commercial ROTEM(®) tests, including FIBTEM(®).

Main Results:

  • Fibrinogen levels and FIBTEM(®) Maximum Clot Formation (MCF) remained within reference ranges up to 24 hours post-trauma.
  • Significant increases in fibrinogen level and FIBTEM(®) MCF were observed at 48 hours post-trauma.
  • A significant correlation (R=0.714, p<0.001) was found between FIBTEM(®) MCF and fibrinogen concentration.

Conclusions:

  • Fibrinogen function undergoes early changes following severe burn trauma.
  • The fibrinogen-sensitive FIBTEM(®) test effectively visualizes these dynamic changes in fibrinogen function.
  • ROTEM(®) provides valuable insights into coagulation status in burn patients.