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Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization
J E Leet1, D R Schroeder, B S Krishnan
1Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
The Journal of Antibiotics
|August 1, 1990
Abstract:
The novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, alpha-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system.