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Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy
J K Kettenring1, A Malabarba, K Vékey
1Merrell Dow Research Institute, Lepetit Research Center, Varese, Italy.
The Journal of Antibiotics
|September 1, 1990
Abstract:
By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class.