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Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives
S Nishimura1, N Yasuda, H Sasaki
1New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
The Journal of Antibiotics
|September 1, 1990
Abstract:
The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.