Supramolecular host-guest interaction for labeling and detection of cellular biomarkers
Sarit S Agasti1, Monty Liong, Carlos Tassa
1Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge St., Boston, MA 02114, USA.
Angewandte Chemie (International Ed. in English)
|November 25, 2011
Abstract:
Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.
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