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Published on: September 20, 2024

A patient with mexiletine-related psychosis

Fnu Shailesh1, Sandeep Singla, Ravi Sureddi

  • 1Division of Cardiovascular Medicine, University of Arkansas for Medical Science, Little Rock, AR, USA.

International Journal of General Medicine
|November 25, 2011
PubMed

Insights

Mexiletine, an antiarrhythmic drug, can cause psychosis. This case was managed by dose reduction and alternative medications for ventricular tachycardia.

Area of Science:

  • Cardiology
  • Pharmacology
  • Neuroscience

Background:

  • Mexiletine is a Class IB antiarrhythmic agent.
  • It is frequently prescribed for ventricular tachycardia management.

Observation:

  • A patient developed psychosis.
  • This adverse effect was linked to mexiletine use.

Findings:

  • Psychosis induced by mexiletine was successfully treated.
  • Treatment involved reducing the mexiletine dosage.
  • Alternative antiarrhythmic medications were employed.

Implications:

  • Highlights a rare adverse effect of mexiletine.
  • Informs clinical practice for managing drug-induced psychosis.
  • Suggests a need for careful patient monitoring during mexiletine therapy.
Keywords:
antiarrhythmicmexiletinepsychosis

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