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Updated: May 27, 2026
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Acute liver failure: a life-threatening disease
Ali Canbay1, Frank Tacke, Johannes Hadem
1Klinik für Gastroenterologie und Hepatologie, Universitätsklinikum Essen. ali.canbay@uni-due.de
Deutsches Arzteblatt International
|November 25, 2011
Summary
Acute liver failure (ALF) in Germany is increasingly caused by toxic substances, not viral hepatitis. Advances in treatment and liver transplantation have improved outcomes, though more data are needed.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Acute liver failure (ALF) affects 200-500 patients annually in Germany.
- Limited data exist on ALF epidemiology, causes, and treatments.
- This review synthesizes current knowledge on ALF.
Purpose of the Study:
- To summarize the current understanding of ALF causes, clinical course, and treatment in Germany.
- To highlight shifts in ALF etiology and identify areas for improved management.
Main Methods:
- Selective review of current literature on ALF.
- Literature search encompassed German and international sources.
Main Results:
- A shift in ALF causes is observed in Germany: toxic substances are now leading, surpassing viral hepatitis.
- Cryptogenic subacute ALF incidence is increasing.
- Mortality has decreased due to improved treatments, liver transplantation, and intensive care.
Conclusions:
- Precise epidemiological data and randomized treatment trials for ALF in Germany are still lacking.
- Significant progress has been made in ALF diagnosis and treatment.
- Multidisciplinary collaboration is crucial for optimal ALF patient management.
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