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Pseudomonas aeruginosa urinary tract infection in children: risk factors and outcomes

M Bitsori1, S Maraki, S Koukouraki

  • 1Department of Pediatrics, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Greece.

The Journal of Urology
|November 26, 2011
PubMed

Insights

Pseudomonas aeruginosa urinary tract infections (UTIs) in children are rare but linked to prior antibiotic use. These infections indicate a need for careful consideration in children with a history of UTIs or recent antibiotic exposure.

Area of Science:

  • Pediatric infectious diseases
  • Urology
  • Microbiology

Background:

  • Pseudomonas aeruginosa is an uncommon cause of urinary tract infections (UTIs), primarily seen in adults with nosocomial or catheter-associated infections.
  • Data on P. aeruginosa UTIs in pediatric populations are limited, necessitating further investigation.

Purpose of the Study:

  • To investigate the characteristics of P. aeruginosa UTIs in children within a defined geographical area.
  • To compare P. aeruginosa UTIs with community-acquired Escherichia coli UTIs in children.

Main Methods:

  • A 12-year retrospective study comparing clinical, laboratory, and radiological data of children with P. aeruginosa UTIs to gender-matched children with E. coli UTIs.
  • Multivariate logistic regression analysis was employed to identify independent risk factors.

Main Results:

  • P. aeruginosa UTIs were associated with a history of previous UTIs, hospitalizations, antibiotic use, urinary tract malformations, vesicoureteral reflux, and abnormal dimercapto-succinic acid scans.
  • Recent antibiotic use (prophylaxis or treatment within 2 months) was the sole independent risk factor for P. aeruginosa UTIs (OR 21.6).
  • P. aeruginosa isolates showed resistance to gentamicin and ceftazidime but remained sensitive to carbapenems and ciprofloxacin.

Conclusions:

  • P. aeruginosa UTIs in children have distinct risk factors and clinical outcomes.
  • Consideration of P. aeruginosa is crucial for predisposed children presenting with UTI symptoms, especially those with a history of recent antibiotic exposure or prophylaxis.
Abstract

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