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Ulipristal acetate: a new emergency contraceptive
Jade L Sullivan1, Marilyn N Bulloch
1University Medical Center, Box 870326, Tuscaloosa, AL, USA.
Expert Review of Clinical Pharmacology
|November 26, 2011
Summary
Ulipristal acetate (UPA), a novel emergency contraceptive, is more effective than levonorgestrel options, delaying ovulation for up to 120 hours. Clinical trials confirm its efficacy and good tolerability for women needing emergency contraception.
Area of Science:
- Pharmacology
- Reproductive Health
- Drug Development
Background:
- Ulipristal acetate (UPA) is a selective progesterone receptor modulator used for emergency contraception.
- Current emergency contraceptives have limitations regarding efficacy and time window.
- Understanding UPA's mechanism and efficacy is crucial for reproductive health.
Purpose of the Study:
- To evaluate the efficacy and safety of ulipristal acetate (UPA) as an emergency contraceptive.
- To compare UPA's effectiveness with existing emergency contraceptive options.
- To determine the optimal dosing interval for UPA.
Main Methods:
- Phase III clinical trials were conducted to assess UPA's efficacy and safety.
- Pharmacodynamic trials investigated UPA's effects on ovulation and the endometrium.
- Data from clinical studies were analyzed to determine efficacy within the 120-hour dosing interval.
Main Results:
- Ulipristal acetate (UPA) effectively delays follicular maturation and ovulation.
- Efficacy of UPA remains consistent within the 120-hour (5-day) post-unprotected intercourse window.
- Adverse drug reactions associated with UPA were minimal and comparable to competitor therapies.
Conclusions:
- Ulipristal acetate (UPA) offers a more effective emergency contraception option with a broader time window.
- UPA's mechanism of action, primarily delaying ovulation, contributes to its enhanced efficacy.
- UPA is well-tolerated, presenting a favorable safety profile for emergency contraception use.
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