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Related Experiment Video

Updated: May 27, 2026

Enumeration of Neural Stem Cells Using Clonal Assays

Enumeration of Neural Stem Cells Using Clonal Assays

Published on: October 4, 2016

JAM-C is an apical surface marker for neural stem cells.

Sandra Stelzer¹, Maik M A Worlitzer, Lamia'a Bahnassawy

¹Institute of Cell Biology, Stem Cell Biology and Regeneration Group, Westfälische Wilhelms-Universität Münster, ZMBE, Münster, Germany.

Stem Cells and Development

|November 26, 2011

Summary

Junctional adhesion molecule-C (JAM-C) is expressed in neural stem cells (NSCs) and progenitor cells. This protein is asymmetrically distributed during cell division, identifying it as a novel marker for neural stem cells.

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Immunocytochemistry: Human Neural Stem Cells

Immunocytochemistry: Human Neural Stem Cells

Published on: August 24, 2007

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Junctional adhesion molecule-C (JAM-C) is a cell surface protein involved in cell-cell adhesion.
Neural stem cells (NSCs) are highly polarized and their self-renewal relies on controlled cell divisions.
The distribution of apical membrane components influences NSC division asymmetry.

Purpose of the Study:

To investigate the expression and localization of JAM-C in neural stem cells.
To determine if JAM-C plays a role in the asymmetric cell divisions of NSCs.

Main Methods:

Immunohistochemistry on embryonic and adult mouse brain tissue.
Analysis of JAM-C expression and localization in neural progenitor and stem cells.
In vivo studies to observe JAM-C distribution during cell division.

Main Results:

JAM-C is expressed in neural progenitor cells and neural stem cells in both embryonic and adult mouse brains.
JAM-C is enriched at the apical surface of these cells.
JAM-C exhibits asymmetric distribution during neural stem cell division.

Conclusions:

JAM-C is identified as a novel surface marker for neural stem cells.
The asymmetric distribution of JAM-C suggests a role in regulating NSC division.
JAM-C may be important for maintaining neural stem cell populations.