Related Experiment Video
Updated: May 27, 2026
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Clinical outcomes of cerebral infarctions in neonates
Yoon Young Yi1, Jun Sook Lee, So Ick Jang
1Department of Pediatrics, College of Medicine, Hallym University and Gangdong Sacred Heart Hospital, Seoul, South Korea.
Insights
Cerebral infarctions in newborns are rare but can cause seizures. This study reviews seven cases, finding that most infants with these brain injuries achieve normal development, aiding outcome prediction.
Area of Science:
- Neurology
- Neonatal Medicine
- Pediatric Neurology
Background:
- Cerebral infarctions are infrequent in neonates but are a significant cause of neonatal seizures.
- Early identification and understanding of risk factors are crucial for managing these conditions.
Purpose of the Study:
- To review clinical presentations, risk factors, diagnostic findings, and outcomes of neonatal cerebral infarctions.
- To explore the relationship between infarction location, electroencephalography (EEG) findings, and neurodevelopmental outcomes.
Main Methods:
- Retrospective review of seven neonates diagnosed with cerebral infarctions.
- Analysis of clinical data, perinatal history, cranial magnetic resonance imaging (MRI), EEG, thrombophilic factors, and follow-up neurodevelopmental assessments.
Main Results:
- Six of seven neonates presented with seizures; one had cyanosis.
- Left middle cerebral artery infarctions were most common (six cases).
- Five neonates had normal development at follow-up; one showed hemiparesis and aphasia, and another had toe-in gait.
Conclusions:
- Neonatal cerebral infarctions, though uncommon, warrant consideration in seizure evaluation.
- Most infants with cerebral infarctions achieve favorable neurodevelopmental outcomes.
- These findings can assist in predicting long-term outcomes for affected neonates.
Abstract:
Cerebral infarctions are uncommon in neonates. However, they should be considered among causes of neonatal seizures. We describe seven neonates with cerebral infarctions. Clinical presentations, perinatal history, perinatal risk factors, cranial magnetic resonance imaging and electroencephalography findings, thrombophilic factors, and clinical outcomes were reviewed. Six patients manifested seizures, whereas one exhibited cyanosis. Six neonates manifested left middle cerebral artery infarctions, and one exhibited a borderzone infarction between the anterior cerebral and middle cerebral arteries. Electroencephalograms indicated epileptiform discharges on the left hemisphere in three neonates with left middle cerebral artery territory infarctions, and epileptiform discharges on both hemispheres in one patient. At most recent follow-up visit, five patients had achieved normal development, whereas one exhibited right hemiparesis and aphasia, and another manifested toe-in gait. These findings may help predict neurodevelopmental outcomes in neonates with cerebral infarctions.
