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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Hydrogen sulfide in cell survival: a double-edged sword
1The School of Kinesiology, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario, P7B 5E1, Canada. gyang@lakeheadu.ca
Expert Review of Clinical Pharmacology
|November 26, 2011
Summary
Hydrogen sulfide (H(2)S), a signaling molecule, paradoxically promotes cell growth while also exhibiting cytotoxic effects. This review explores its dual actions and underlying mechanisms in mammalian cells.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- Hydrogen sulfide (H(2)S) is recognized as a crucial signaling molecule involved in cellular processes.
- H(2)S exhibits a dual role, acting as both a stimulator of cell growth and a potential cytotoxic agent.
Purpose of the Study:
- To review the dual cytoprotective and cytotoxic effects of H(2)S in mammalian cells.
- To elucidate the signaling mechanisms underlying these opposing actions of H(2)S.
- To discuss the pharmacologic regulation and clinical significance of H(2)S.
Main Methods:
- Literature review of existing research on H(2)S effects in mammalian cells.
- Analysis of studies detailing H(2)S signaling pathways.
- Examination of evidence regarding H(2)S production regulation and clinical applications.
Main Results:
- H(2)S demonstrates context-dependent effects, promoting cell survival and growth in certain conditions.
- Conversely, H(2)S can induce cytotoxicity at specific concentrations or under particular cellular environments.
- Various signaling pathways mediate the distinct cytoprotective and cytotoxic actions of H(2)S.
Conclusions:
- H(2)S possesses "Janus-faced" properties, essential for its diverse physiological roles.
- Understanding H(2)S signaling mechanisms is key to harnessing its therapeutic potential.
- Pharmacologic modulation of H(2)S offers promising avenues for clinical intervention.
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