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Related Experiment Video

Updated: May 27, 2026

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

Processing radical prostatectomies: an alternate-slice method is comparable with total embedding.

Cesar A Llanos¹, Clifford Blieden, Stephen E Vernon

¹Department of Pathology, University of Miami Miller School of Medicine, FL 33136, USA. CLlanos2@med.miami.edu

Annals of Diagnostic Pathology

|November 26, 2011

Summary

This summary is machine-generated.

A new partial prostate sampling method, the alternate slice technique, offers comparable results to total prostate embedding. This method reduces tissue processing while maintaining accuracy in cancer diagnosis and staging for radical prostatectomy specimens.

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Area of Science:

Pathology
Surgical Oncology

Background:

Radical prostatectomy specimen processing lacks a standardized method in histopathology.
Total prostate sampling has potential disadvantages, and alternatives lack proven advantages.

Purpose of the Study:

To compare the efficacy of a partial sampling method (alternate slice) against total prostate embedding for radical prostatectomy specimens.

Main Methods:

Consecutive radical prostatectomy specimens were processed using both total embedding and the alternate slice method.
The alternate slice method involved reviewing sections from anterior, middle, and posterior thirds of the prostate.
Seminal vesicles, bladder neck, and margins were evaluated in both methods.

Main Results:

Total embedding averaged 30 blocks; alternate slice averaged 18 blocks.
High correlation was observed for Gleason score (87.5%), extraprostatic extension (97.9%), and pathologic staging (97.9%).
Complete correlation was achieved for margin status and perineural invasion.

Conclusions:

The alternate slice partial sampling method demonstrates favorable comparison to total embedding.
This method offers a potentially more efficient approach to prostate cancer specimen processing.