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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Folate in skin cancer prevention.

J D Williams1, Elaine L Jacobson, H Kim

  • 1Division of Medicinal Chemistry, Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA, williams@pharmacy.arizona.edu.

Sub-Cellular Biochemistry
|November 26, 2011
PubMed
Summary

Skin cancer risk may be reduced by topical folate. Folate is essential for DNA repair and genomic integrity, and protecting it in sun-exposed skin is key for cancer prevention.

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Area of Science:

  • Dermatology and Carcinogenesis
  • Nutritional Biochemistry

Background:

  • The skin acts as a barrier against environmental damage, particularly from ultraviolet radiation (UVR), a known carcinogen.
  • Melanin and skin pigmentation are adaptive defenses against UVR, but a balance with essential micronutrient production (Vitamin D) and preservation (folate) is hypothesized.
  • Folate photodegradation in skin may increase cancer risk in individuals with lower pigmentation in high UVR areas.

Purpose of the Study:

  • To investigate the role of folate in skin health and its potential as a strategy for skin cancer prevention.
  • To explore the challenges of folate delivery and stability within the skin.

Main Methods:

  • The study focuses on the biochemical roles of folate in DNA repair and genomic stability.
  • It considers the impact of UVR on folate levels in the skin.
  • The research explores the potential of topical folate delivery systems.

Main Results:

  • Folate plays a critical role in maintaining skin integrity and function.
  • UV radiation can lead to folate degradation in the skin.
  • Topical application of folate shows promise for protecting sun-exposed skin.

Conclusions:

  • Folate is crucial for skin health and cancer prevention.
  • Protecting folate from UV-induced degradation in the skin is important.
  • Effective topical delivery of folate represents a viable strategy for preventing sun-induced skin damage and cancer.