Successful pregnancy complicated by persistent pneumothorax in a patient with lymphangioleiomyomatosis (LAM) on sirolimus
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Updated: May 27, 2026

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Published on: January 23, 2026
M Faehling1, S Frohnmayer, M Leschke
1Klinik für Kardiologie und Pneumologie, Klinikum Esslingen, Esslingen; 2Lungenfacharztpraxis, Esslingen. m.faehling@klinikum-es.de
Abstract:
We report a successful pregnancy in a patient with longstanding LAM on treatment with sirolimus. During temporary discontinuation fo sirolimus in early pregnancy, lung function declined but recovered after resumption of sirolimus. Pregnancy was complicated by a persistent pneumothorax which was treated surgically postnatally. The child has had a normal development despite exposure to low dose sirolimus intermittently during early embryonal and mid-fetal life.
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