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Gene-environment interaction in chronic disease: a European Science Foundation Forward Look
Harald Renz1, Ingo B Autenrieth, Per Brandtzæg
1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany. renzh@med.uni-marburg.de
The Journal of Allergy and Clinical Immunology
|November 29, 2011
Summary
The rise in chronic inflammatory diseases like asthma and allergies is linked to modern lifestyles. International collaboration and resource prioritization are crucial for developing effective prevention and treatment strategies.
Area of Science:
- Immunology and Public Health
- Investigating the rise of chronic inflammatory diseases and their links to modern lifestyle factors.
Background:
- Growing incidence of chronic inflammatory diseases (asthma, allergies, IBS) in Western populations.
- Concern over modern lifestyle's role in triggering innate immune responses.
- Healthcare research faces challenges in addressing future population health needs.
Framework:
- Need for advanced tools to understand intrinsic and extrinsic mechanisms of chronic inflammatory diseases.
- Prioritizing resources for efficient scientific and societal initiatives.
- Establishing state-of-the-art practices through interdisciplinary collaboration.
Implementation:
- National and international collaboration in Europe and beyond.
- Promoting efficient exchange of best practices.
- Consultation with experts from industry, academia, and interest organizations.
Implications:
- Development of effective treatment and prevention strategies for chronic inflammatory diseases.
- Efficient amelioration of the increasing prevalence of these conditions.
- Recommendations targeting academic research, science funders, and policymakers.
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