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Development of formulation device for periodontal disease
Yasuhiko Sato1, Takuma Oba, Norio Watanabe
1Drug Formulation Department, Central Research Laboratories, Kaken Pharmaceutical Co. Ltd., Fujieda, Shizuoka, Japan. sato_yasuhiko@kaken.co.jp
Drug Development and Industrial Pharmacy
|November 29, 2011
Summary
Developing new periodontal treatments requires viscous formulations for growth factors. This study addresses challenges in preparing these formulations, leading to a novel device that simplifies the process and reduces preparation time.
Area of Science:
- Periodontology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Periodontal disease treatment requires tissue regeneration beyond surgical intervention.
- Growth factors are promising regenerative medications but face stability challenges in solution.
- Viscous formulations are necessary for effective periodontal regenerative medication delivery.
Purpose of the Study:
- To identify challenges in preparing viscous formulations for lyophilized growth factors.
- To develop and validate a prototype administration device for improved formulation preparation.
- To streamline the preparation of periodontal regenerative therapies.
Main Methods:
- Conventional vials and ampoules were used to prepare a lyophilized placebo and a viscous dissolution liquid.
- A prototype administration device with an integrated mixing system was designed and fabricated.
- The functionality of the prototype device was assessed for its ability to prepare viscous formulations.
Main Results:
- Preparation of viscous formulations using conventional containers presented issues like poor dissolution and air bubble formation.
- The prototype administration device demonstrated a useful mixing system.
- The developed device significantly shortened the preparation time for viscous formulations.
Conclusions:
- The prototype administration device effectively addresses the challenges of preparing viscous periodontal formulations.
- This innovation has the potential to improve the clinical application of growth factor-based periodontal regenerative therapies.
- Further development could enhance the accessibility and efficiency of periodontal regenerative medicine.
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