Reduced source activity of event-related potentials for affective facial pictures in schizophrenia patients

The ability to recognize facial affect is impaired in schizophrenia patients. This study compared source activities of the event-related potentials (ERPs) for affective facial pictures between schizophrenia patients and healthy controls. Twenty-three schizophrenia patients (11 females) and 24 healthy controls (12 females) were recruited. The standardized low-resolution brain electromagnetic tomography (sLORETA) source activities of four ERP components (P100, N170, N250, and P300) were compared between schizophrenia patients and healthy controls in response to fearful, happy, and neutral facial expressions. Group differences of sLORETA source activities were found only for the N170 component in response to the fearful face. Source activities in the middle frontal gyrus and inferior frontal gyrus were lower in schizophrenia patients compared to healthy controls. Source activity in the insula was lower in male schizophrenia patients compared to male healthy controls. Source activities in the superior temporal gyrus, middle temporal gyrus, insula and inferior frontal gyrus were lower in male compared to female schizophrenia patients. However, there was no gender difference on ERP source activities in the healthy controls. These results support the hypothesis that schizophrenia patients have reduced N170 current source density in response to fearful faces. The area exhibiting reduced current source density includes the frontal and temporal cortex. The present results suggest that there may be gender differences in facial affect processing in schizophrenia patients.