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Laboratory aspects of prenatal microarray analysis

Allen N Lamb1

  • 1Cytogenetics and Genomic Microarray Laboratory, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA. allen.n.lamb@aruplab.com

Clinics in Laboratory Medicine
|November 29, 2011
PubMed

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...