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Related Experiment Video

Updated: May 27, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

Red-cell and platelet alloimmunisation in pregnancy.

Michael Egbor¹, Peter Knott, Amarnath Bhide

¹Department of Obstetrics and Gynaecology, and Fetal Medicine Unit, St Helier University Hospital, Surrey, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology

|November 29, 2011

Summary

Red-cell alloimmunisation management has improved with anti-D and ultrasound. Future strategies may use fetal blood typing from maternal blood to refine anti-D prophylaxis, reducing alloimmunisation risks.

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Published on: May 21, 2015

Area of Science:

Obstetrics and Gynecology
Immunology
Fetal Medicine

Background:

Red-cell alloimmunisation management transformed by anti-D prophylaxis and ultrasound.
Reduced D antigen alloimmunisation leads to increased focus on c and Kell antibodies.
Non-invasive ultrasound diagnostics are highly reliable for fetal anaemia detection.

Purpose of the Study:

To review advancements in red-cell alloimmunisation management.
To highlight the impact of non-invasive diagnostics and molecular techniques.
To discuss future directions in prophylaxis and treatment.

Main Methods:

Review of current clinical practices in managing red-cell alloimmunisation.
Analysis of ultrasound-based diagnostic techniques for fetal anaemia.
Exploration of molecular methods for fetal blood group determination.

Main Results:

Anti-D administration and ultrasound have significantly improved outcomes.
Ultrasound-guided intravascular transfusions are effective for fetal anaemia treatment.
Fetal blood group determination via free fetal DNA offers potential for targeted anti-D use.

Conclusions:

Modern diagnostics and treatments have revolutionized red-cell alloimmunisation management.
Molecular advancements promise more precise prophylactic strategies.
Prophylaxis for non-D antibodies remains a challenge.